Thomas Klockgether Selected Research

Therapeutics

4/2023	[Gene Therapy for Ataxias].
1/2020	Effects of Rivastigmine on Patients with Spinocerebellar Ataxia Type 3: A Case Series of Five Patients.
7/2019	Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3 (SCA3-tDCS): rationale and protocol of a randomized, double-blind, sham-controlled study.
1/2017	Effects of acetyl-DL-leucine on cerebellar ataxia (ALCAT trial): study protocol for a multicenter, multinational, randomized, double-blind, placebo-controlled, crossover phase III trial.
5/2011	Milestones in ataxia.
11/2010	Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry.
1/2010	Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial).
1/2007	Parkinsonism & related disorders. Ataxias.
4/2006	Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms.
6/2005	Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.

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Thomas Klockgether Research Topics

Disease

47	Ataxia (Dyssynergia) 03/2024 - 05/2004
22	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 11/2023 - 10/2003
19	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 11/2023 - 09/2004
19	Parkinson Disease (Parkinson's Disease) 01/2020 - 05/2002
14	Inflammation (Inflammations) 01/2020 - 04/2002
13	Friedreich Ataxia (Friedreich's Ataxia) 03/2024 - 07/2008
13	Alzheimer Disease (Alzheimer's Disease) 01/2020 - 04/2002
11	Disease Progression 01/2023 - 05/2003
10	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 10/2003
7	Cerebellar Ataxia (Dysmetria) 01/2022 - 06/2011
6	Multiple Sclerosis 05/2012 - 02/2003
5	Dementia (Dementias) 01/2020 - 01/2011
4	Cognitive Dysfunction 01/2020 - 04/2003
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 05/2012 - 05/2003
3	Multiple System Atrophy 01/2022 - 01/2010
3	Lymphoma (Lymphomas) 12/2020 - 04/2003
3	Huntington Disease (Huntington's Disease) 01/2020 - 09/2006
3	Neuroblastoma 01/2012 - 10/2003
2	Ganglion Cysts (Ganglion) 01/2023 - 01/2022
2	Atrophy 01/2022 - 06/2020
2	Movement Disorders (Movement Disorder) 01/2020 - 10/2003
2	Pain (Aches) 01/2016 - 09/2010
2	Mitochondrial Diseases (Mitochondrial Disease) 05/2011 - 06/2002
2	Autoimmune Diseases (Autoimmune Disease) 09/2009 - 01/2009
2	Sepsis (Septicemia) 09/2008 - 04/2007
2	Diabetes Mellitus 11/2006 - 01/2005
2	Hypertension (High Blood Pressure) 11/2006 - 01/2005
2	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 10/2006 - 02/2003
2	Neoplasms (Cancer) 06/2006 - 08/2002
2	Amyloid Plaque 10/2005 - 06/2005
2	Glioma (Gliomas) 02/2003 - 06/2002
1	Orthostatic Hypotension (Postural Hypotension) 09/2023
1	Restless Legs Syndrome (Restless Legs) 02/2023
1	Paraplegia (Spastic Paraplegia) 01/2023
1	Breast Neoplasms (Breast Cancer) 06/2020
1	Leukoencephalopathies 01/2020
1	Parkinsonian Disorders (Parkinsonism) 01/2020
1	Frontotemporal Dementia (Semantic Dementia) 01/2020
1	Asthma (Bronchial Asthma) 01/2020
1	Hereditary Spastic Paraplegia 01/2020
1	Dystonia (Limb Dystonia) 01/2020
1	Chorea (Rheumatic Chorea) 01/2020

Drug/Important Bio-Agent (IBA)

22	Biomarkers (Surrogate Marker)IBA 11/2023 - 01/2010
11	polyglutamineIBA 10/2023 - 10/2003
11	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2003
10	Ataxin-3IBA 10/2023 - 10/2003
9	indium arsenide (InAs)IBA 10/2023 - 03/2012
9	PPAR gammaIBA 09/2009 - 06/2002
5	Retinaldehyde (Retinal)IBA 01/2023 - 03/2005
5	DNA (Deoxyribonucleic Acid)IBA 09/2017 - 04/2005
5	Amyloid beta-PeptidesIBA 04/2006 - 04/2002
4	Levodopa (L Dopa)FDA LinkGeneric 09/2023 - 05/2002
4	Interleukin-6 (Interleukin 6)IBA 10/2005 - 02/2003
3	IronIBA 01/2022 - 01/2010
3	salicylhydroxamic acid (SHAM)IBA 01/2022 - 07/2019
3	protein kinase C gamma (PRKCG)IBA 08/2020 - 02/2014
3	idebenoneIBA 06/2019 - 07/2008
3	AntibodiesIBA 01/2019 - 02/2003
3	Amyloid (Amyloid Fibrils)IBA 01/2017 - 10/2003
3	Dopamine (Intropin)FDA LinkGeneric 05/2009 - 06/2004
3	Transcription Factors (Transcription Factor)IBA 01/2009 - 10/2005
3	CytokinesIBA 09/2008 - 10/2003
3	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2006 - 10/2003
2	Glycoproteins (Glycoprotein)IBA 01/2023 - 02/2003
2	acetylleucineIBA 12/2021 - 01/2017
2	Cytarabine (Cytosar-U)FDA LinkGeneric 12/2020 - 04/2003
2	Methotrexate (Mexate)FDA LinkGeneric 12/2020 - 04/2003
2	N-Methylaspartate (NMDA)IBA 01/2019 - 05/2004
2	EnzymesIBA 09/2010 - 10/2005
2	factor V LeidenIBA 06/2010 - 06/2002
2	Factor XIII (Coagulation Factor XIII)IBA 06/2010 - 01/2005
2	CopperIBA 04/2010 - 09/2006
2	LigandsIBA 01/2009 - 10/2005
2	Interleukin-1beta (Interleukin 1 beta)IBA 09/2008 - 10/2005
2	Nicotine FDA Link 01/2008 - 01/2005
2	Lipoprotein(a)IBA 11/2006 - 01/2005
2	Cystathionine beta-Synthase (Serine Sulfhydrase)IBA 10/2006 - 10/2004
2	Glucose (Dextrose)FDA LinkGeneric 02/2006 - 08/2005
2	Pioglitazone (Actos)FDA Link 10/2005 - 06/2005
2	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 08/2005 - 10/2003
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 08/2003 - 04/2002
1	sperm releasing substanceIBA 01/2023
1	Coenzyme A (CoA)IBA 01/2023
1	SodiumIBA 01/2022
1	Essential Amino AcidsIBA 12/2021
1	Tumor Necrosis Factor Ligand Superfamily Member 14IBA 12/2020
1	Protein Kinases (Protein Kinase)IBA 08/2020
1	anti-amphiphysin autoantibodyIBA 06/2020
1	Hexachlorobenzene (HCB)IBA 06/2020
1	Rivastigmine (Exelon)FDA LinkGeneric 01/2020
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2020
1	EsterasesIBA 01/2020
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2020

Therapy/Procedure

10	Activities of Daily Living (ADL) 03/2024 - 02/2006
10	Therapeutics 04/2023 - 06/2005
5	Drug Therapy (Chemotherapy) 12/2020 - 08/2002
3	Transcranial Direct Current Stimulation 01/2022 - 07/2019
2	Radiotherapy 12/2003 - 04/2003
1	Patient Care 01/2023
1	Duration of Therapy 12/2021